Curcumin has neuroprotective effects in rotenone-induced Parkinson disease in mice by affecting bcl-۲ family gene expressions

Background:  One of the common diseases in different societies is Parkinson's disease (PD), for which no suitable treatment has been found yet. Curcumin a natural compound has shown neuroprotective properties in many studies. Therefore, in this research, the administration of this compound to female mice was studied. Methods: Induction of PD in mice was done by administering ۲ mg rotenone, and then a Rotarod test was performed on female mice. Also, ۵۰ mg/kg of curcumin was administered every day for ۲۱ days and its effects were evaluated in PD mice. Finally, the expression levels of bax and bcl-۲ were measured in the brain of female mice by RT-PCR technique. GraphPad Prism V.۸ software was used for data analysis. Results: Induction of PD led to a decrease in the performance of mice in the Rotarod test. However, the administration of curcumin to these mice improved their performance. Also, overexpression of bax and downregulation of bcl-۲ genes were observed in the brains of PD mice, to whom the administration of curcumin downregulated bax gene and overexpressed bcl-۲ gene. Conclusion: Curcumin has neuroprotective effects in PD conditions, which can be attributed to the change in expressions of the bcl-۲ family gene. More studies are needed in this field.

کلیدواژه ها:

Gene ، Curcumin ، Neuroprotection ، RT-PCR