Promising gene delivery applications of archaeal lipid vesicles

Drug and gene carrier vesicles (also referred to as controlled release systems) are advanced dosage forms utilized for disease diagnosis, prevention, and cure. The design rationale is to supply an adequate quantity of the medicaments or diagnostic agents to the pathological sites (target cells) at the right time frame to attain maximum therapeutic outcome with minimum or ideally no adverse effects and toxicity. These systems aim to optimize drug administration, absorption, distribution, metabolism, and elimination. Gene delivery systems can vary widely in their structure, size, charge, mechanism of action, and applications, meeting different therapeutic needs and serving various patient populations. Lipid and phospholipid-based carriers, specifically archaeal lipid (lipids extracted from Archaeobacteria) vesicles are gaining increasing attention as potential delivery systems in industry and research. In this regard, this review has tried to cover critical micro- and nano aspects of gene delivery applications of archaeal lipid vesicles.

کلیدواژه ها:

Gene carrier vesicles ، Controlled release systems ، Phospholipid-based carriers ، Archaeobacteria