Association between BMI and Leptin Levels in Women with Primary Infertility: A Cross-Sectional Study

Background & Objective: Primary infertility affects a significant proportion of couples and is often attributed to female factors. Obesity, which is associated with increased levels of the hormone leptin, is a known risk factor for female infertility. The present study was conducted with aim to investigate the association between BMI and leptin levels in females with primary infertility.Materials and Methods: This cross-sectional study was performed on ۱۰۰ women with primary infertility at Al-Nuaman Hospital and Al-Salama private hospital from September ۲۰۲۲ to March ۲۰۲۳. The participants were divided into four groups: Group ۱ (normal weight, fertile), Group ۲ (overweight infertile), Group ۳ (obese infertile), and Group ۴ (severely obese infertile) women, each consisting of ۲۵ participants, categorized based on their BMI: normal BMI (۱۸.۵–۲۴.۹ kg/m²), overweight BMI (۲۵–۲۹.۹ kg/m²), obesity BMI (≥۳۰ kg/m²), and severely obese BMI (۳۵-۴۰ kg/m²). The mean leptin levels were compared between the four groups using ANOVA, and the association between BMI and leptin levels was assessed using Pearson's correlation coefficient.Results: There was a highly significant correlation between primary infertility and the parameters (BMI and leptin) (P<۰.۰۰۱) and showed a positive correlation between leptin and BMI.Conclusion: It was shown that females with primary infertile and a high BMI have elevated serum leptin levels. This underscores the importance of weight management in addressing primary female infertility.

کلیدواژه ها:

Body Mass Index ، Leptin ، Primary infertility ، Female infertility