Role of Flt۴ in Skin Protection against UVB Radiation: A System Biology Approach The Role of Flt۴ in Skin Protection against UVB Radiation

Abstract Background: Although the application of ultraviolet B (UVB) in phototherapy of human skin is a common therapeutic method, it is known as a risk factor for skin cancer. This study aims to assess the role of differentially expressed genes (DEGs) to find the critical one that is mainly responsible for skin protection against UVB radiation.Methods: The gene expression profiles of irradiated mice by UVB that issued skin protection against exposure are extracted from Gene Expression Omnibus (GEO) and analyzed by GEO۲R. The significant DEGs are assessed via gene ontology (GO) analysis and the critical individuals are investigated via action mapping.Results: Thirty-eight significant DEGs that provide skin resistance against UVB irradiation were determined. Among the query DEGs, ۲۶ individuals were related to ۴۳ biological terms. Flt۴, F۳, Tspan۶, Cblb, and Itgb۶ were highlighted as the critical DEGs to promote skin protection against UVB irradiation.Conclusion: The finding indicates that Flt۴ is the key DEG that is mainly responsible for protecting skin from UVB exposure. Keywords: UVB; Skin; Mouse; Gene ontology; Flt۴