Comparison of the Histopathological Effects of Selenium Nanoparticles and Cerium Oxide Nanoparticles in Cadmium-intoxicated Rabbits Service Unavailable

This study compared the effects of selenium nanoparticles and cerium oxide nanoparticles on biochemical and histopathological changes of cadmium-intoxicated rabbits. Forty white New Zealand rabbits were equally distributed into four groups. The Control group received saline orally while the negative control group received six-week oral administrations of cadmium ۵ mg/kg. The third group received oral administration of selenium nanoparticles (۰.۸ mg/kg) and cadmium (۵mg/kg). The fourth group received cerium oxide nanoparticles (۰.۸ mg/kg) and cadmium (۵mg/kg). After six weeks, serum was obtained by the conventional methods, and then rabbits were sacrificed to obtain liver, kidney, and testis tissues for histopathological examinations. The oral administrations of Cadmium ۵ mg/kg caused significant elevations in serum liver enzyme levels, serum BUN, serum creatinine, and lipid peroxidation levels (P<۰.۰۵). The histopathological investigations showed necrosis and inflammations in the liver, kidney, and testis of rabbits. Selenium nanoparticles oral administrations at a dose of ۰.۸ mg/kg significantly reduced liver enzymes, malondialdehyde (MDA) content, and histopathological changes. The cadmium intoxicated rats treated with Cerium oxide nanoparticles showed normal biochemical and histopathological parameters (P<۰.۰۵). The current study proved the hepatoprotective and nephroprotective effects of selenium nanoparticles and cerium oxide nanoparticles in cadmium intoxicated rabbits; however, cerium oxide nanoparticles were more effective.This study compared the effects of selenium nanoparticles and cerium oxide nanoparticles on biochemical and histopathological changes of cadmium-intoxicated rabbits. Forty white New Zealand rabbits were equally distributed into four groups. The Control group received saline orally while the negative control group received six-week oral administrations of cadmium ۵ mg/kg. The third group received oral administration of selenium nanoparticles (۰.۸ mg/kg) and cadmium (۵mg/kg). The fourth group received cerium oxide nanoparticles (۰.۸ mg/kg) and cadmium (۵mg/kg). After six weeks, serum was obtained by the conventional methods, and then rabbits were sacrificed to obtain liver, kidney, and testis tissues for histopathological examinations. The oral administrations of Cadmium ۵ mg/kg caused significant elevations in serum liver enzyme levels, serum BUN, serum creatinine, and lipid peroxidation levels (P<۰.۰۵). The histopathological investigations showed necrosis and inflammations in the liver, kidney, and testis of rabbits. Selenium nanoparticles oral administrations at a dose of ۰.۸ mg/kg significantly reduced liver enzymes, malondialdehyde (MDA) content, and histopathological changes. The cadmium intoxicated rats treated with Cerium oxide nanoparticles showed normal biochemical and histopathological parameters (P<۰.۰۵). The current study proved the hepatoprotective and nephroprotective effects of selenium nanoparticles and cerium oxide nanoparticles in cadmium intoxicated rabbits; however, cerium oxide nanoparticles were more effective.

کلیدواژه ها:

Selenium ، Nanoparticles ، Liver ، Kidney ، Toxicity