Palmoplantar Psoriasis: Treatment with Calcipotriol and Local UVA Radiation Compared with Local PUVA

Abstract INTRODUCTION: Palmoplantar psoriasis could hardly be differentiated from chronic tylotic eczema both clinically and histologically. The most commonly used therapeutic options for palmoplantar psoriasis are long-term therapy with topical corticosteroids and local PUVA. Frequently, it is a recalcitrant disease. We investigated the efficacy and tolerability of the combination of topical calcipotriol with local UVA radiation in comparison with local PUVA therapy.METHODS: In a total of ۴۳ patients with palmoplantar psoriasis, ۳۳ were given ۱۵ sessions of local UVA radiation and topical calcipotriol and the remainder received ۱۵ sessions of local PUVA (psoralen + UVA radiation).RESULTS: The statistical analyses of the results showed that the effect and tolerability of both therapeutic modalities are comparable.CONCLUSION: Combination of topical calcipotriol and local UVA radiation is an optional corticosteroid-free therapeutic modality for palmoplantar psoriasis. It has a comparable effectiveness and tolerability with local PUVA. Keywords: Psoriasis palmo-plantar Calcipotriol Psoralen Clinical Trial