Clinical Efficacy of Topical CoQ۱۰ and Vitamin-E Eye-drop in Retinopathy of Prematurity

Abstract Treatment strategy for retinopathy of prematurity (ROP) includes anti-vascular endothelial growth factor (anti-VEGF) and/or laser therapy. The aim of this study was to investigate the clinical effects of topical Coqun® eye drop (CoQ۱۰ and Vitamin-E) on the progression and treatment of ROP. One hundred and ten infants with type ۱ ROP who received Coqun® (Coqun group) and ۱۳۱ infants with type ۱ ROP who did not receive Coqun® (control group) were included in this retrospective analysis. All patients were follow-up until retinal vascular maturation was complete. Intravitreal bevacizumab (IVB) injection or laser photocoagulation (LPC) were apply if needed. Treatment frequency, treatment response and mean follow-up time were compare. The number of IVB was similar between the groups, but infants in the Coqun group underwent significantly fewer LPC procedure than those in the control group (P = ۰.۰۲۲). The mean follow-up time was significantly shorter in infants receiving Coqun® in stage ۱ ROP (P = ۰.۰۱۷) and similar in stages ۲-۴ ROP and aggressive posterior retinopathy of prematurity (APROP). The number of LPC procedure was fewer in the Coqun group in APROP (P = ۰.۰۴۳). These results indicate that faster retinal vascular maturation in infants with low-grade ROP and lower number of treatments with APROP could be achieve with Coqun® therapy. Epub: October ۱, ۲۰۱۹.