Outcomes after bilateral implantation of AcrySof IQ PanOptix trifocal intraocular lens: a prospective interventional study

Abstract Background: Implantation of multifocal intraocular lenses (IOLs) is becoming increasingly popular for the treatment of visual demands at various distances in patients undergoing phacoemulsification cataract surgery. We aimed to assess the visual performance and rates of photic phenomena, posterior capsule opacification (PCO), and spectacle independence in patients with bilateral implantation of the AcrySof® IQ PanOptix® multifocal IOL model TFNT۰۰ at one and six months postoperatively. Methods: This prospective interventional cohort study included adult patients who underwent uneventful phacoemulsification cataract surgery with bilateral implantation of AcrySof® IQ PanOptix® IOL. Uncorrected and corrected visual acuities at far, intermediate, and near distances were measured preoperatively and at the one- and six-month postoperative follow-up examinations. The rates of photic phenomena, postoperative need for near and distance spectacles, and PCO were also recorded. Results: We included ۱۶۴ eyes of ۸۲ patients with a male-to-female ratio of ۳۸ (۴۶.۳%) to ۴۴ (۵۳.۷%) and a mean (standard deviation [SD]) age of ۵۲.۳۷ (۷.۶۲) years. There were statistically significant improvements in the visual acuities of both eyes across all distances at the one- and six-month follow-up examinations compared to the preoperative values (all P < ۰.۰۰۱), except for corrected near visual acuity in the right eye (P > ۰.۰۵) at six-month. We also detected significant postoperative improvements in visual acuities of both eyes across all distances at the six-month follow-up compared to values at the one-month follow-up (all P < ۰.۰۵), except for corrected near visual acuity in the right eye (P > ۰.۰۵). The photic phenomenon was reported by ۱۲ (۱۴.۶%) of the ۸۲ patients at the six-month postoperative follow-up. Five (۶.۱%) and eight (۹.۸%) of the ۸۲ patients reported using spectacles for distance and near, respectively. Additionally, PCO developed in ۱۹ (۱۱.۶%) of the ۱۶۴ included eyes, although it was not clinically significant at six months. Conclusions: The AcrySof® IQ PanOptix® IOL model TFNT۰۰ is recommended for use, given its excellent performance in all ranges of vision, a high rate of spectacle independence, and a good safety profile. Future comparative studies with longer follow-up periods are warranted to verify superiority of its performance over that of other available multifocal IOLs.