Histopathological observations on vulvar transmissible venereal tumor in a dog

The transmissible venereal tumor (TVT) is a contagious and sexually transmissible neoplasia with a low metastatic rate and no breed or sex predilection. The present study describes the occurrence of the vulvar TVT in a ۴-year-old female mix-breed dog. Based on owner information, within the previous ۱-month period, the mass had become evident. Macroscopically, it was hyperemic and ulcerated. Finally, complete surgical removal was selected. Microscopically, the mass was composed of loose sheets, rows, and cords of relatively uniform round to ovoid cells. By immunohistochemical staining, the neoplastic cells were positive for vimentin and were negative for cytokeratin, desmin, S-۱۰۰, CD۳, and CD۷۹a. Transmissible venereal tumor was diagnosed based on the anatomical location of the tumor and histopathological findings. The dog was treated weekly, for ۶ weeks, with vincristine. No new growth of the mass was observed ۴ months after the end of therapy. According to the literature, complete surgical excision and treatment with antimitotic agents, such as vincristine sulfate is effective.

کلیدواژه ها:

Dog ، TVT ، Pathology ، IHC ، Chemotherapy