Nanotopography and its importance in cell imprinting

Technologies based on cell cultures are widely used in many fields, including regenerative medicine, drug analysis, and toxicity evaluation. Cell imprinting is the process of using gels or polymers to mimic the natural topology of cell membranes to make an environment for controlling cell fate.An efficient physical method for manipulating cells via material-extracellular matrix interactions is provided by nanotopography. Unlike chemical signals, mechanical signals derived from nanotopography reach the nucleus more swiftly, steadily, and efficiently. The cellular microenvironment’s extracellular matrix is critical in controlling how cells behave. Further upstream mechanotransductive pathways are regulated by the interactions with the extracellular matrix. Also, manipulating artificial surfaces’ nanotopographic characteristics can change stem cells’ fate. Enhancing nanotopographical characteristics results in favorable stem cell capabilities and optimizes the efficacy of regenerative medicine. An overview of the process of producing nanotopographical features for cell imprinting to get desired cell behaviors is given in this article. Furthermore, the various uses of cell imprinting in disease modeling, cell therapy, and regenerative medicine are discussed.

کلیدواژه ها:

Nanotopography ، Cell Imprint ، Regenerative Medicine ، Cell Fate