Copper-Catalyzed One-Pot Synthesis of poly-Substituted Thiophen Derivatives fromSulfonylketenimines Chemistry

An efficient synthesis of highly substituted thiophenes was developed by means of sulfonylketenimines in amulti-step reaction including heterocumulene system containing sulfur and nitro alkanes with acidic α-hydrogen.The speed and easiness of conducting this four-component reaction under mild conditions and using availablematerials makes it an ideal method for the synthesis of high purity substituted thiophenes with sulfonamide moiety.

کلیدواژه ها:

Sulfonylketenimine ، Substituted Thiophen ، Copper Iodide ، Heterocumulene ، Nitro Alkanes ، Carbon Disulfide