The Value of Anti-Mullerian Hormone as a Prognostic Indicator for Successful Live Birth Outcomes in Patients Experiencing Recurrent Pregnancy Loss

Background & Objective: Consecutive miscarriages are considered recurrent pregnancy loss (RPL), which affects ۱-۲% of women and may be unpleasant for couples attempting to conceive. Patients and healthcare professionals confront a difficult situation in this regard. The present study was conducted with aim to investigate the potential role of anti-mullerian hormone (AMH) in predicting the rate of live birth in women with RPL who are trying to conceive naturally.Materials & Methods: This cross-sectional study involved ۶۰ pregnant women from Baghdad and Al-Najaf infertility centers (June ۲۰۲۲ - June ۲۰۲۳), recording age, gestational age, miscarriage frequency, fetal outcomes, parity, and number of live births. AMH levels were measured using Minividas Biomeriux ۲۰۲۰ (France), followed by assessments of FSH and Estradiol. Low AMH prompted further tests for autoimmune and genetic disorders. Inclusion criteria were all pregnant women with spontaneous or induced pregnancies and a history of recurrent miscarriage. Exclusions were those with unexplained pregnancy loss and male factor infertility.Results: The mean age of participants was ۳۲.۸ years, with ۴۶.۷% aged ۲۱-۳۰ years. AMH levels were higher in females aged ۲۱-۳۰ years, those with two abortions, and those with two parities. A significant correlation was observed between age over ۴۰ years and a history of four abortions.Conclusion: AMH emerges as a crucial biomarker that intertwines with various aspects of female reproductive health, including miscarriage history, age, and parity. Future research is needed to deeply investigate the mechanisms behind these associations and offer more comprehensive insights into female fertility dynamics.

کلیدواژه ها:

Anti-mullerian hormone ، predictor ، Live Birth ، Recurrent Pregnancy Loss