The Pathological Characteristics of Cervical Conization and Cervical Intraepithelial Cancer Recurrence Rate Based on Different Age Groups

Background & Objective: Immunosuppression, HPV persistence, and smoking are the main-related risk factors of Cervical Intraepithelial Neoplasia (CIN) recurrence. However, age as a basic factor may be a main factor related to CIN recurrence. Therefore, our study aimed to detect the potential role of women's age in CIN recurrence.Materials & Methods: This cross-sectional study was conducted on ۳۲۹ patients who underwent conization in the gynecology-oncology clinics of Arash and Imam Khomeini hospitals affiliated with Tehran University of Medical Sciences between March ۲۰۱۶ and March ۲۰۲۱.Results: Totally, ۳۲۹ cases were enrolled in the study. Most women were in their thirties. CIN recurrence was about ۱۰.۰% (۳۲ cases). The CIN recurrence rate was ۸.۹% in women younger than ۳۰, ۱۰.۲% in ۳۰-۴۰, ۱۱.۳% in ۴۰-۵۰, and ۵.۶% in ۵۰–۶۰ decades. There was no significant (p-value=۰.۸۰۲) difference in recurrence rate among age groups. There was a significant (p-value=۰.۰۲۳) difference in the frequency of endocervical involvement regarding age category, women aged ۴۰ to ۵۰ had the most frequent marginal involvement with ۲۶.۸%, while there was no significant (p-value=۰.۸۰۲) difference in frequency of marginal involvement regards age category.Conclusion: CIN cases with age higher than ۴۰ years need to have more caution and tight follow-up visit after conization.

کلیدواژه ها:

Conization ، age groups ، Prognosis ، Recurrence ، Uterine Cervical Neoplasms