Prevalence of Tuberculosis among People Who Use Drugs in Iran: A Systematic Review and Meta-analysis

Background: Drug use, especially injecting drug use, is associated with a higher risk of tuberculosis (TB). This study aimed to systematically review the prevalence of TB among people who use drugs (PWUD) in Iran.Methods: A systematic search was conducted in international and national databases. All studies that provided data on the prevalence of TB among PWUD based on screening tests and diagnosis from ۱۹۹۰ up to August ۲۰۱۹ were assessed. Metaanalysis was performed on the prevalence of active TB among people who inject drugs (PWID).Findings: Overall, nine studies were included. The studies were carried out from ۱۹۹۴ to ۲۰۱۲ in seven out of the ۳۱ provinces of Iran. Seven studies provided data on the prevalence of TB diagnosis among ۱۰۸۷ PWID. The pooled prevalence of TB diagnosis was ۱۰.۱% (۹۵% CI: ۴.۵, ۱۵.۸) in studies carried out in hospitals and ۰.۵۴% (۹۵% CI: ۰.۰۴, ۱.۰۴) in other settings.Conclusion: The present review suggests an approximately ۴۰ times higher prevalence of TB among PWID compared to the general population. However, most of the included studies were conducted on a subpopulation of drug users, and caution should be exercised when generalizing the findings.

کلیدواژه ها:

Prevalence ، drug users ، Tuberculosis ، Iran