Intermolecular Interactions between Sacubitril and Valsartan in Entresto: A QTAIM Study

In this study, we used quantum theory of atoms in molecules (QTAIM) to investigate thesacubitril/valsartan complex as a double-acting drug (Entresto) used for treating heart failure. Our findingsshow no covalent interaction between valsartan and the carboxylate groups and amide group of sacubitrilatwhich may decrease the effectiveness of treatment of sacubitrilat

کلیدواژه ها:

Sacubitril ، Valsartan ، Antihypertensive drug ، QTAIM