Activation of the carbon-hydrogen bond of phenols

A method was proposed for the activation of the Carbon-Hydrogen bond of phenols and activation ofmolecular oxygen and the subsequent of the phenol substrate without the use of halides or external oxidants.According to this method, phenols are oxidized to quinones and then ortho-amination through an atomiceconomicaland most sustainable dehydrogenative oxidation and the amination method. This oxidation occursthrough a radical activity of copper and oxygen gas under mild reaction conditions and with a broad substratescope.

کلیدواژه ها:

Phenols ، Activation of Carbon-Hydrogen bond ، Quinones ، Ortho amination