Development of an efficient and simple method for the synthesis of dimethyl fumarateAPI at room temperature via one-pot, one-step reaction

Dimethyl fumarate (DMF) is a drug and prodrug with various medicinal uses and is used in thetreatment of Multiple sclerosis (MS). One of the common methods for the synthesis of DMF is throughesterification reactions. It involves the reaction between fumaric acid and methanol in the presence of a catalyst.Esterification process requires precise control of temperature, reaction time and reactant ratio to achieve highefficiency. In current report, we have developed a process for the synthesis of dimethyl fumarate from thereaction between fumaric acid and methanol using HCl ۲۰% and Zinc chloride as catalysts at room temperature.This method is able to synthesize dimethyl fumarate active pharmaceutical ingredient (API) at room temperaturein short reaction time and excellent yield

کلیدواژه ها:

Dimethyl fumarate ، API ، Synthesis ، Drug