Nano-encapsulated limonene: Utilization of drug-in-gama cyclodextrin to improve thestability and enhance the antioxidant activity

Drug-in-gama cyclodextrin (DC) was used to encapsulated limonene (LIM). The complexationmechanism of LIM/γ-CD inclusion complex was analysed, showing that Lim was entrapped into the cavity of γ-CD through electrostatic and hydrophobic interaction with a molar ratio of ۱:۱. Notably, DC formulation not onlyreduced Lim volatilization in ۲۵℃, but also enhanced the free radical (DPPH·) scavenging ability of LIM. Insummary, LIM-DC formulation improved the stability and enhanced the antioxidant activity of LIM. DCnanocarrier system is suitable to preserve volatile and hydrophobic compounds, enlarging their application inpharmaceutics industries. DC can be used as a nanocarrier of food matrix for volatile and hydrophobiccompounds.

کلیدواژه ها:

Nanocapsule ، Gama cyclodextrin ، Limonene