Synthesis and Characterization of a New Chemical Sensor for the Detection of Zinc Ionswith A Significant Red Shift in Emission

A novel fluorescent chemosensor for zinc ion measurement was created and studied. It has an amazingred shift in emission spectra based on naphthalene groups. After complexing with Zn۲+ ions, sensor H۲L was seento have an unusually strong red shift in emission. It was determined that the limit of detection (LOD) was۴.۹۸×۱۰-۹ M. The synthesized compound's fluorescence behavior is similar to that of IMP and INH logic gates[۱]. Among the numerous analytical methods that are available for the detection of cations, fluorescentchemosensors have been intensively studied due to their distinct advantages in terms of sensitivity, selectivity,instantaneous response, and local observation. Therefore, significant progress has been made on thedevelopment of fluorescent sensors for a wide variety of metal ions. Zinc plays important roles in variousbiological processes. Zinc is found in over ۲۰۰ enzymes and hormones in mankind for example, the zinc sites inprotein domains play structural, catalytic and cocatalytic roles zinc is needed for DNA synthesis, RNAtranscription, mitosis, and cell activation. Zinc is also suspected to play a role in neurological disorders such asParkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and epileptic seizures. It is also importantfor hair and skin health, eyesight, cognitive functions, and even taste and smell. In particular, many fluorescentsensors have been actualized to detect and analyze of zinc ions, but most of them show enhancement, turn on,or little spectral shift. In the other hand, the greatest challenge for detecting Zn۲+ comes from the interferenceof other transition metal ions, in particular Cd۲+, which exhibits many properties similar to those of Zn۲+ becausethey are in the same group of the periodic table. Therefore, they cause similar spectral changes whilecoordinated with fluorescent sensors [۲]. Thus, there is a great need for developing Zn۲+ -selective sensors thatcan distinguish Zn۲+ from Cd۲+ with high sensitivity and selectivity under physiological conditions. Molecular logicgates are also one research focus of chemistry for further miniaturization in information technology since thefirst AND logic gate was mimicked with optical signals by de Silva et al. Various chemical systems have beendeveloped to get different functions such as AND, OR, IMP, INH and their integrated operations. Schiff basecompounds can be easily synthesized by the condensation reactions of carbonyl group and primary amines. Thiskind of molecules are known to have strong binding abilities to the metal ions and display different opticalproperties from the ligands themselves, making them good candidates for cation probes [۳].

کلیدواژه ها:

Chemosensor ، Fluorescence ، Zinc Sensor ، Linear Tetraamine ، Logic Gate