Regioselective, Biginelli-type Reaction of Aldehyde, Phenylacetone and Urea/ThioureaKinetic vs Thermodynamic Control

An efficient regioselective synthesis of various ۳,۴-dihydropyrimidin-۲(۱H)-one (DHPMs) via a threecomponentBiginelli-type condensation of aldehyde, phenylacetone and urea/thiourea under two differentbased-catalyzed conditions is described. In kinetic control path, lithium N, N-diisopropylamide was used as thebase. Thermodynamic control path was run with NaH as the base, under reflux status.

کلیدواژه ها:

۳ ، ۴-Dihydropyrimidin-۲(۱H)-one ، Kinetic-thermodynamic ، Biginelli-type