Synthesis of polysubstituted pyridines via nitrogen-doped graphene catalyzed one-potmulticomponent reaction under solvent-free conditions

Nitrogen-doped graphene as a dual acid–base catalyst efficiently catalyzes the multicomponentreaction between arylaldehydes, diethylacetylenedicarboxylates, malononitrile and ammoniumacetate undersolvent-free conditions at ۸۰°C. Polysubstituted pyridine derivatives were produced in high to excellent yieldsand in short reaction times. The structures of the synthesized pyridines were established by Ft-IR, ۱H and ۱۳CNMR spectroscopic analysis. The advantages of this method include the in-situ oxidation of prepared ۱,۴-dihydropyridines, one-pot procedure, solventless system, operational simplicity and no columnchromatography.

کلیدواژه ها:

Nitrogen-Doped Graphene ، Multicomponent Reaction ، Pyridine