Synthesis of ۶/۷/۵-Fused Heterocyclic Skeletons through Transition-Metal-FreeIntramolecular Double Hydrofunctionalization of Alkyne

We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with nitrogenand oxygen nucleophilic groups to construct valuable ۶/۷/۵-fused heterocyclic products. This post-Groebke–Blackburn–Bienaymé reaction introduces a new class of functionalized isocyanides. Transition-metal-freecyclization, scale-up reaction, broad substrate scope, and high atom economy were some features of the presentprotocol.

کلیدواژه ها:

Double hydrofunctionalization ، ۶/۷/۵-fused heterocyclic ، alkyne