A Review of the Role of Bacterial Infectious Agents in Male and Female Infertility

Background and Aims: Infertility is a prevalent global health issue affecting millions of couples worldwide. While various factors contribute to infertility, the involvement of bacterial infectious agents has gained increasing attention in recent years. This review aims to provide a comprehensive overview of the role of bacterial infections in male and female infertility by examining relevant research studies. Methods: The research method employed in this review involved an extensive search and analysis of scientific literature, including peer-reviewed articles, research papers, and clinical studies. Databases such as PubMed, Scopus, and Google Scholar were utilized to collect relevant publications. The search terms included "bacterial infections," "male infertility," and "female infertility," among others. Results: The findings of this review highlight the potential impact of bacterial infectious agents on male and female reproductive health. Several bacterial pathogens have been implicated in the development of infertility, such as Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Escherichia coli. In males, these pathogens can lead to epididymitis, prostatitis, and urethritis, which may result in impaired sperm function and production. In females, bacterial infections can cause pelvic inflammatory disease (PID), tubal damage, and endometritis, leading to tubal factor infertility and recurrent miscarriages. Furthermore, the review explores the mechanisms by which bacterial infections contribute to infertility. These mechanisms include direct damage to reproductive organs, induction of inflammation, alteration of the vaginal microbiota, and production of reactive oxygen species. The review also discusses the diagnostic methods employed to identify bacterial infections in infertility cases, including culture-based techniques, polymerase chain reaction (PCR), and serological tests. Conclusion: In conclusion, bacterial infectious agents play a significant role in male and female infertility. Understanding the impact of bacterial infections on reproductive health is crucial for the development of effective diagnostic and treatment strategies. Further research is warranted to elucidate the underlying mechanisms, improve diagnostic accuracy, and explore novel therapeutic approaches to mitigate the detrimental effects of bacterial infections on fertility. By addressing bacterial infections, healthcare providers can enhance the management and outcomes of infertility, ultimately improving the quality of life for affected individuals and couples.

کلیدواژه ها:

Infertility ، Bacteria ، Male ، Female