Short-term effects of antenatal betamethasone on fetal cardiovascular and circulation status: A quasi-experimental observational (before-after) study

Background: The administration of antenatal corticosteroid is a standard treatment to reduce the rate of perinatal mortality and morbidity; however, there is limited evidence regarding the potential effects of betamethasone on the constriction of the ductus arteriosus (DA). Objective: This study aimed to investigate the short-term effects of antenatal betamethasone on fetal cardiovascular and circulation status. Materials and Methods: This quasi-experimental observational (before-after) study was conducted on ۳۲ singleton fetuses. The participants were healthy pregnant women with a diagnosis of placenta accreta spectrum who were eligible for ۲ doses of betamethasone and referred to prenatal care clinic, Vali-E-Asr hospital, Tehran, Iran from January ۲۰۲۱-May ۲۰۲۲. The results of fetal echocardiography and Doppler sonography were compared before and after the administration of antenatal corticosteroid therapy. Results: Following betamethasone injection, significant increases were observed in peak systolic and diastolic velocity of the DA without constriction of the DA (p < ۰.۰۰۱, p = ۰.۰۰۲ respectively). However, no significant changes were observed in right ventricular function, tricuspid valve function, Doppler of ductus venous, and peak systolic velocity of the aortic isthmus (p > ۰.۰۵). Doppler examination of the uterine, umbilical, and middle cerebral arteries also showed no significant changes (p > ۰.۰۵). Conclusion: Considering the benefits of antenatal corticosteroid therapy, its administration seems reasonable in preterm births. The transient changes in ductal blood flow are not prohibitive.

کلیدواژه ها:

Betamethasone ، Premature birth ، Ultrasonography ، Doppler ، Echocardiography ، Fetus. ، بتامتازون ، زایمان زودرس ، سونوگرافی ، داپلر ، اکوکاردیوگرافی ، جنین.