A computational study to validate a parallel plate bioreactor for bone tissue engineering applications
سال انتشار: 1403
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 57
فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
ISME32_162
تاریخ نمایه سازی: 15 تیر 1403
چکیده مقاله:
Worldwide, over a million bone injuries occur annually, in which bone grafting procedures must be performed. A bone tissue engineering strategy suggests an auspicious alternative to current medical treatments. Shear stress is a dominant mechanical stimulus that increases the gene expression. Parallel plate chambers are frequently used to examine the response of biological cells to a constant wall shear stress. In this study, we did a computational study to validate a parallel plate bioreactor used to enhance the MSCs differentiation. Our results show that the height of the channel has a great impact on the WSS magnitude. Furthermore, we have evaluated the effect of different oscillatory regimes on the WSS experienced by a cell layer cultured on a polymeric scaffold. These promising results provide a numerical basis for exploring the MSCs fate at different frequencies. Also, the results aid tissue engineers to test and design a suitable bioreactor prior to manufacturing process.
کلیدواژه ها:
Bone Tissue Engineering ، Computational Modeling ، Mechanical Modulation ، Oscillatory Flow Parallel Plate Bioreactors
نویسندگان
Sahar Jianian tehrani
MSc student, Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
Bahman Vahidi
PhD, Associate professor, Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran