A computational study to validate a parallel plate bioreactor for bone tissue engineering applications

Worldwide, over a million bone injuries occur annually, in which bone grafting procedures must be performed. A bone tissue engineering strategy suggests an auspicious alternative to current medical treatments. Shear stress is a dominant mechanical stimulus that increases the gene expression. Parallel plate chambers are frequently used to examine the response of biological cells to a constant wall shear stress. In this study, we did a computational study to validate a parallel plate bioreactor used to enhance the MSCs differentiation. Our results show that the height of the channel has a great impact on the WSS magnitude. Furthermore, we have evaluated the effect of different oscillatory regimes on the WSS experienced by a cell layer cultured on a polymeric scaffold. These promising results provide a numerical basis for exploring the MSCs fate at different frequencies. Also, the results aid tissue engineers to test and design a suitable bioreactor prior to manufacturing process.

کلیدواژه ها:

Bone Tissue Engineering ، Computational Modeling ، Mechanical Modulation ، Oscillatory Flow Parallel Plate Bioreactors