Preparation of eugenol nanoemulsion by the spontaneous method

۱. Background: The present study aims to enhance the water solubility of eugenol throughnanoemulsion formulation with spontaneous method and evaluate the particle size, surface load,thermodynamic stability, and drug release of the nanoemulsion.۲. Materials and Methods: Eugenol, oleic acid, and surfactant tween ۸۰ were mixed using a vortex for ۱minute. Isopropyl alcohol was added as the aqueous phase and the mixture was polymerized using amagnet on a stirrer for ۳ minutes. Thermodynamic stability studies were conducted on selectednanoemulsions.۳. Results: from the selected nanoemulsions, those with the smallest particle sizes, measuring(۹۵,۱۰۱,۸۱,۷۷) nm were identified. Additionally, all formulations exhibited a surface charge of ۲۵mv. eugenol nanoemulsion formulation demonstrated a reduced release rate compared to the solutionstate, indicating the potential for sustained drug release.۴. Conclusion: The spontaneous formation of nanoemulsion is regarded as a highly cost-effectiveapproach that offers time and material savings, along with the production of stable nanoemulsions.this characteristic renders it particularly suitable for industrial applications necessitating high-volumeproduction.

کلیدواژه ها:

nanoemulsion ، eugenol ، essential oil ، surfactant ، particle size ، spontaneous method ، stability