Physiological disturbances and histological damages of reproductive system in male rats resulted by metformin
محل انتشار: مجله علوم زیستی خاورمیانه، دوره: 20، شماره: 4
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 29
فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_CJES-20-4_008
تاریخ نمایه سازی: 31 خرداد 1403
چکیده مقاله:
The current study was designed to evaluate the effects of metformin in some physiological and histological parameters of reproductive system in the diabetic male rats experimentally. Forty rats were randomly divided into four groups. The (control) first group was treated with normal saline; the second was infected group which included rats diabetic experimentally treated by alloxan; the third and fourth groups were induced diabetic experimentally and received metformin suspension (۱۵۰ mg kg-۱ daily) at one and two doses respectively. Twelve hours was time between these two doses. Reproductive ability was measured by determination of some physiological parameters as count sperm, malformations, motility, dead sperm, weights of sex organs (testes, epididymis, prostate glands and seminal vesicles) and the damaged testicular structure. The present results indicated that the administrated metformin at high doses led to significant decrease (p < ۰.۰۵) in total count of sperm, motility and in weights of all sex organs such as testes, epididymis, prostate glands and seminal vesicle, while significant increase (p < ۰.۰۵) in sperm abnormalities and dead sperm. Also, the results showed that the diabetes and exposure to metformin caused many malformations of sperm such as shattered sperm, the lacking, hooked and quirky tail, while the abnormalities of head included the lacking, Globozoospermia and elliptical head. The histological damages in testicular structure were observed including the destroyed and raised thickness of connective tissue among seminiferous tubules, necrosis and reduction numbers of spermatocytes along with the congestion of blood vessels. Many histological alterations occurred clearly due to treated with high dose of metformin after diabetic experimentally including the most affected structural troubles as large fracture of seminiferous tubules, expansion of bloody congestion and raise of necrosis in testicular structure.
کلیدواژه ها:
نویسندگان
Fatima Aziz Mahdi Al-badry
Biology Department, College of Education for Pure Sciences, University of Thi-Qar, Iraq
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :