Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes

By reacting trimethoprim and hippuric acid at a molecular weight of ۱, the amide ligand molecule was produced. By reacting ligands with CoCl۲.۲H۲O, NiCl۲.۶H۲O, and K۲PtCl۶ in a ۲:۱ [L:M] mole ratio, cobalt (II), nickel (II), and platinum (IV) complexes were produced. All of the produced compounds were studied by taking readings of their FT-IR, UV-Vis, TG/DTA, ۱H-NMR, CHN, melting point, molar conductivity, magnetic susceptibility, and chloride. All the synthesized compounds had anticancer, antibacterial, and antifungal activities against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida, respectively.

کلیدواژه ها:

Drug ، Trimethoprim ، Amide structure ، Hippuric acid ، Anticancer