Detection of Mycoplasma pneumoniae in Pediatric Patients with Community-Acquired Pneumonia in Western Iran
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 37
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شناسه ملی سند علمی:
JR_IEM-10-1_005
تاریخ نمایه سازی: 27 خرداد 1403
چکیده مقاله:
Background: Mycoplasma pneumoniae strains are among the main causes of community-acquired pneumonia (CAP) in humans. Early detection of this microorganism is important to improve treatment efficiency. This study aimed to detect M. pneumoniae (MP)-specific immunoglobulin M (IgM) and MP DNA among pediatric patients with CAP during one week after admission.
Materials & Methods: From September ۲۰۱۹ to February ۲۰۲۰, ۵۶ CAP patients aged ۵ to ۱۵ years were investigated for the presence of MP. Throat swabs for molecular detection of MP and blood samples for detection of cold agglutinins and MP-specific IgG and IgM antibodies were collected at admission. Blood and throat samples were taken again ۶ days after admission. Macrolide resistance due to mutations in the ۲۳S rRNA gene was also investigated.
Findings: MP-specific IgM was found in ۱۹.۶%, IgG in ۱۶.۱%, and cold agglutinins in ۲۶.۸% of CAP patients. The combination of IgM+IgG was not found. Tachypnea and the need for intensive care were more common in IgM-positive than in IgM-negative patients. Only four patients were positive for MP DNA, of whom two patients carried macrolide-resistant isolates. One isolate had an A۲۰۶۳G mutation and the other had an A۲۰۶۴C mutation.
Conclusion: To the best of our knowledge, there are no data on the epidemiology of MP in ۵-۱۵-year-old patients with CAP in Kurdistan, western Iran. The possibility of false-positive or -negative reactions and co-presence with other microorganisms could not be excluded.
کلیدواژه ها:
نویسندگان
Roghayeh Amini
Department of Pediatrics, Faculty of Medicine, Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Safoura Derakhshan
Environmental Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan university of Medical Scie
Masoumeh Abedini
Department of Pediatrics, Faculty of Medicine, Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran.
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