Traumatic Brain Injury and the Risk of Parkinson’s Disease

Background: Traumatic Brain Injury (TBI) is considered as a risk factor for several neurological diseases, including Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease. Objectives: The aim of the present study was to evaluate the occurrence of post-TBI PD. Methods: This descriptive cross-sectional study was performed on two groups of patients referred to Al-Zahra Hospital in Isfahan in ۲۰۲۳. The first group consisted of patients who had suffered TBI ۱۰ years ago. The second group included Parkinson's Disease (PD) patients. Census sampling was performed in both groups based on the number of patients referred to the selected center. The collected data were analyzed using SPSS ver.۲۲ and p<۰.۰۵ was considered as the significance level. Results: Out of ۱۲۶۰ PD patients, ۲۵ (۱.۹۸%) had TBI and out of ۲۰۰ TBI patients, ۲ (۱%) had PD. There was a significant relationship between the severity of moderate TBI and the PD incidence in patients in both groups (first group p = ۰.۰۰۰۱ and second group p = ۰.۰۰۲) (p <۰.۰۵). There was no significant relationship between the frequency of TBI and its mechanism with the PD incidence in both groups (p >۰.۰۵). The odd ratio of developing PD with a mean of ۷ years after TBI diagnosis was ۰.۳۶, which increased to ۱.۴۲ with increasing the TBI duration to the mean age of ۳۰ years. Conclusion: The findings of the present study confirmed the need for information on the treatment and prevention of post-TBI PD. It should be noted that other underlying factors such as aging, genetics, etc. can also be effective in the development of PD.

کلیدواژه ها:

Traumatic Brain Injury ، Parkinson's ، Severity of Injury