Investigating the MRI lesions and their Relationship with cognition condition according to BICAMBS in patients with multiple sclerosis disorder

Background: Multiple sclerosis (MS) is a common inflammatory disease affecting the central nervous system, causing demyelination and axon loss. Cognitive impairment is also prevalent in patients. A study aimed to measure MRI findings and their relation to cognitive impairments in MS patients. Methods: This cross-sectional analytical study was conducted on ۵۰ patients with a definite diagnosis of MS at Firoozgar Hospital in Tehran, Iran, from ۲۰۱۹ to ۲۰۲۱. MRI, complete neurological and psychological examinations, and information documented in the records were used to prepare a complete list of clinical, neurological, and psychological manifestations. The severity of these symptoms was assessed, and patients were scored according to the Expanded Disability Status Scale (EDSS), Cholinergic Pathways Hyperintensities Scale (CHIPS), and Brief International Cognitive Assessment (BICAMS) criteria.  Results: In this study, there were ۳۶ females and ۱۴ males with mean age of ۳۴.۱۴±۹.۴ years. Relapse and remission was observed in ۷۰% of patients. CHIPS score had a significant relationship with spinal symptoms. Also, BICAMS score of patients showed a significant relationship with limbic involvement in MRI. The third ventricular diameter and CHIPS score were positively correlated with BICAMS score. Patients' EDSS score had a significant relationship with Symbol Digit Modalities Test (SDMT) score.  Conclusion: In this study, it was found that there is a significant relationship between the size of the third ventricle and the CHIPS score with decreased cognitive function in MS patients. Therefore, MRI can be used to suspect cognitive disorders in MS patients.

کلیدواژه ها:

Multiple sclerosis ، MRI ، Cognition