The effect of garlic juice on the increase of catalase and glutathioneperoxidase activity in the epididymis of streptozotocin (STZ)-induced diabeticmale rats

Medicinal plants have been used to mitigate reproductive complications of diabetes. Weinvestigated the effects of garlic juice on the activity of catalase and glutathione peroxidaseenzymes in diabetic rats. Twenty-four male Wistar rats were divided into four groups(n=۶/group): Control group (C), Diabetic group (D), Diabetic group receiving ۰.۵ ml/۱۰۰ gb.w of garlic juice (D+G۰.۵), Diabetic group receiving ۱ ml/۱۰۰ g b.w of garlic juice(D+G۱). The experimental period was ۳۰ days. The activity of catalase and glutathioneperoxidase enzymes decreased in the epididymis of diabetic rats. Treatment with garlic juicein doses of ۰.۵ and ۱ ml/۱۰۰ g bw increased the activity of these enzymes, with dose ۱ml/۱۰۰ g b/w being more effective. It is suggested that garlic can act as an antioxidant forreproductive complications of diabetes.

کلیدواژه ها:

Diabetes mellitus ، epididymis ، Garlic ، Catalase ، Glutathione peroxidase