Recent Advances in Medicinal Chemistry with Benzothiazole-Based Compounds: An In-Depth Review

Among the many natural ingredients and pharmacological drugs that contain heterocyclic compounds, benzothiazole (BTA), and its derivatives stand out as particularly significant. BTA analogs provide a great deal of structural diversity, which has been helpful in the quest for new therapeutic drugs, and BTA itself displays a variety of pharmacological features. Because each BTA derivative has its own unique set of pharmacological effects, it is clear that this class of chemicals is intriguing. Medicinal chemistry based on BTAs is a hot subject right now, with lots of new research and discoveries happening in the field. In particular, there are a plethora of BTA-based compounds that have found widespread clinical use as highly effective medications for a wide range of disorders. Current developments of BTA-based compounds in medicinal chemistry as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial, and other medicinal agents are presented in this work systematically and thoroughly. More effective diagnostic agents, pathologic probes, and BTA-based medications that are both active and less toxic, can be rationally designed, according to the authors of this review study.

کلیدواژه ها:

Benzothiazole ، Heterocyclic compounds ، medicinal chemistry ، Therapeutic drugs