Comparison of Pregnancy Outcomes in Pregnant Women with Positive and Negative Anti-thyroid Peroxidase Antibody

Background and Objective: Thyroid-related adverse pregnancy outcomes can be analyzed by Anti-thyroid peroxidase antibody (TPO-Ab). However, whether women with anti-thyroid peroxidase antibody (TPOAb) positivity have a higher risk of poor pregnancy outcomes is debatable. The aim of present study was to comparison of pregnancy outcomes in pregnant women with positive and negative TPO-Ab. Methods: This cross-sectional study was conducted on pregnant women with positive anti-TPO Ab (n= ۱۰۸) and negative anti-TPO Ab (n=۳۴۰) referring to Imam Khomeini Hospital and Ahvaz clinics from January ۲۰۲۰ to December ۲۰۲۰. The pregnancy outcomes, including gestational diabetes mellitus (GDM), preeclampsia, miscarriage, preterm birth, placental abruption, IUFD, IUGR, and TSH level, were compared between the two groups by SPSS software using student t-test and Chi-square test.Results: The mean TSH level was significantly different in women with negative TPO-Ab than those with positive TPO-Ab (Mean (SD): ۲.۲۵(۱.۴۷) vs. ۴.۸۲(۹.۳۸), P<۰.۰۰۰۱). In addition, ۸۱ (۷۵.۰۰%) women in the positive anti-TPO group and ۱۰۴ (۳۰.۵۸%) in the negative anti-TPO group had high TSH (P<۰.۰۰۱). The frequency of GDM in positive anti-TPO Ab pregnant women was significantly higher than that in the negative anti-TPO Ab group (۴۶.۲۹% vs. ۳۴.۱۱%, P=۰.۰۲۹). The results also indicated an enhancement in the rate of miscarriage (۱۵.۷۴% vs. ۴.۱۱%, P<۰.۰۰۱) and preterm parturition (۱۳.۸۸% vs. ۳.۵۲%, P<۰.۰۰۱) in positive anti-TPO Ab women. Conclusions: Presence of positive anti-TPO Ab was significantly associated with preterm delivery, abortion and GDM in pregnancy. Treatment with Levothyroxine can reduce the risk of adverse pregnancy outcomes in women who are positive for TPOAb. .

کلیدواژه ها:

Pregnancy Outcome ، anti-thyroid autoantibody ، TSH ، GDM