The Role of P۴HB and SOX۴ in Prostatic Carcinoma and Their Clinical Significance

Background & Objective: Prostatic adenocarcinoma (PAC) is the second most prevalent cancer and the fifth leading cause of cancer death in men worldwide. Additionally, pathologists may face problems diagnosing it reliably and may need more than one marker. Thus, the search for new immunohistochemical biomarkers becomes mandatory. This study aims to investigate P۴HB and SOX۴ expression in prostatic carcinoma, their possible roles, and clinical significance.Methods: This retrospective study included fifty-six cases of PAC and an equal number of nodular prostatic hyperplasia (NPH) that were immunohistochemically stained by P۴HB and SOX۴. The results of expression were compared between PAC and NPH cases, followed by correlations with available clinicopathological parameters.Results: There was a highly significant difference between PAC and NPH regarding P۴HB and SOX۴ expressions in favor of PAC (both P<۰.۰۰۱). ROC curve analysis of the diagnostic power of P۴HB showed ۷۹% sensitivity, ۷۶% specificity, ۷۶.۵%, and an area under the ROC curve of ۰.۸۴۵, while SOX۴ showed (۸۹%, ۱۰۰%, and ۰.۹۴۶, respectively). P۴HB and SOX۴ expression showed a direct correlation (P<۰.۰۰۱). Moreover, SOX۴ showed a significant inverse relation with ERG (P=۰.۰۴۷). There was a significant correlation between P۴HB and SOX۴ and Gleason score (P<۰.۰۰۱). Moreover, P۴HB expression was significantly associated with lymphovascular invasion (P=۰.۰۱۳), while SOX۴ expression showed a significant association with perineural invasion (P=۰.۰۵).Conclusion: SOX۴ and P۴HB seem to have diagnostic and prognostic value in PAC. While there was a direct correlation between SOX۴ and P۴HB, an inverse relationship between SOX۴ and ERG was detected.

کلیدواژه ها:

Diagnosis ، Erg ، Prostatic adenocarcinoma ، Prognosis ، P۴HB ، SOX۴