Synthesis and characterization of Gabapentin-Zn۲ Al-LDH nanohybrid and investigation of its drug release and biocompatibility properties on a laboratory scale.

Due to their high biocompatibility, Layered Double Hydroxides can be used as hosts in drug delivery systems. In Layered Double Hydroxide-drug hybrids, medicinal properties including stability in the physiological environment of the Body are investigated. The current research work is the synthesis and characterization of a new hybrid of LDH, which forms the nanocomposite of Gabapentin-Zn۲Al-LDH. Gabapentin was selected as a drug model and intercalated in Zn۲Al-LDH layers by co-precipitation method under a nitrogen atmosphere. To determine the structural characteristics of the Gabapentin-Zn۲Al-LDH nanohybrid, the structure of Gabapentin-Zn۲Al-LDH was investigated under X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy. The size of nanohybrid particles in three dimensions X, Y, and Z was reported as ۷۲, ۴۳, and ۵۸ nm, respectively. Finally, to evaluate biocompatibility and drug release properties, drug delivery and MTT assay tests for biocompatibility were performed. and acceptable results were obtained.

کلیدواژه ها:

Layered double hydroxides ، Drug release ، Nanohybrid ، gabapentin