Diagnostic Value of H-FABP, PCT, Lp-PLA۲, and Cytokines in Acute Myocardial Infarction

Background and Objective: Myocardial infarction (MI) is one of the highest leading causes of death worldwide. Many biomarkers are universally accepted in clinical practice as crucial diagnostic biomarkers in acute MI. The current study aims to introduce new sensitivity biomarkers to aid the diagnosis and to facilitate faster decision-making in the emergency department. Materials and Methods: A total of ۵۰ patients, diagnosed with acute myocardial infarction, in Nasiriyah Heart Center, and ۳۰ age-matched healthy individuals were studied. Serum Cardiac Troponin I (cTnI), Myoglobin (MYO), Creatine kinase (CK-MB), Procalcitonin (PCT), Heart-type fatty acid binding protein (H-FABP), Lipoprotein-associated phospholipase A۲ (Lp-PLA۲), High sensitive C reactive protein (hsCRP), were determined by electro-chemiluminescence immunoassay. Blood sugar and serum total cholesterol, triglycerides, LDL, VLDL, and HDL were determined by using Cobas C۳۱۱ photometric assays. Serum IL-۶ was assayed by electro-chemiluminescence immunoassay, while, IL-۹, IL-۱β, and TNF-α were assayed by ELISA. Results: In comparison with healthy control, patients with acute MI showed significant elevation of the serum levels of cTnI, CK-MB, MYO, CRP, H- FABP, PCT, TNF-α, IL-۱β, IL-۹, and IL-۶. Conclusion: The present study suggests that, in addition to cTnI, CK-MB, and MYO, many other mediators such as CRP, H-FABP, PCT, and cytokines are sensitive to the diagnosis of MI. Furthermore, using human monoclonal antibodies that selectively neutralize cytokines may provide additional insight into cytokines-targeted therapies.

کلیدواژه ها:

CK-MB ، CRP ، H-FABP ، IL-۶ ، Lp-PLA۲MI ، Myoglobin ، PCT ، Troponin