Anticancer Potential of Phenolic Extract from Spirulina Platensis Against Esophagus Cancer Cells

Background and Objective: Algae phenolic extracts have received special attention because of their effective and efficient antioxidant properties and their obvious effects in inhibiting various diseases related to oxidative stress, such as cancer. This study aimed to document the phenolic extract of Spirulina platensis against cancer cell line SK-GT-۴ and regular cell line HBL۱۰۰. Materials and Methods: Phenolic compounds were extracted from S. platensis, and the extract was checked for its anticancer activity by MTT. The constituents of phenolic extract were analyzed using high-performance liquid chromatography (HPLC). Results: The results showed that the half maximal inhibitory concentration value for Phenolic extract was ۳۶.۵۲ µg/mL for ۵۰% of cell death. HPLC analysis revealed that the compounds with possible therapeutic effects are gallic acid, ferulic acid, cinnamic acid, syringic acid, and vanillic acid, which have anticancer activity. Conclusion: The results of this study point out that the S. platensis phenolic extract has anticancer potential, and the phytoconstituents contributed to the anticancer effects.

کلیدواژه ها:

Anticancer ، Apoptosis ، HPLC ، Phenolic compounds ، SK-GT-۴ ، Spirulina platensis