Synthesis of Highly Functionalized ۱,۲,۳-Benzotriazines from Isocyanides, Aniline and Dialkyl azadicarboxylate via Cu-Catalyzed Intramolecular C-H Activation Reactions

Tandem synthesis of a novel class of substituted ۱,۲,۳-benzotriazines derivatives is achieved with good yields via the Cu-catalyzed intramolecular C-H activation reaction of isocyanides, aniline and dialkyl azadicarboxylate in acetonitrile at room temperature. The existence of one-pot conditions, availability of a starting material-catalyst, the absence of column chromatography and a high yield of products are among the advantages of this method. The structures are confirmed spectroscopically (۱H- and ۱۳C-NMR, IR and EI-MS) and through elemental analyses.

کلیدواژه ها:

C-H Activation ، Dialkyl azadicarboxylate ، Cu-catalyzed ، ۱ ، ۲ ، ۳-Benzotriazines ، Isocyanides ، Aniline