Preparation Chitosan-Alginate nanoparticles from Ferula Gummosa Gum for colon cancer (SW-۴۸۰) treatment

Herbal medicine has received great attention as promising approach for cancer treatment owning to their natural base and minimal side-effects. In this research, the potential application of chitosan-alginate nanoparticles (NPs) extracted from Ferula Gummosa Gum in colon cancer were investigated. Phenol and flavonoid content of the plant were measured to identify the antioxidant potential of the F. Gummosa Gum. Moreover, MTT and wound healing analysis were conducted on the cancer cells to evaluate the performance of the Chitosan-Alginate NPs extracted from F. Gummosa Gum in colon cancer treatment. According to the results, ۵۰ μg/mL of F. Gummosa Gum contains ۸.۹ mgEGA and ۲.۸ mgEQ of phenol and flavonoid. IC۵۰s ۴۸h of Chitosan-Alginate NP was recorded as ۴.۴۶۲ μg/mL. The wound healing results revealed that the Chitosan-Alginate NP at concentration over IC۵۰ could efficiently affect the colon cancer cells migration disability. This study suggests Chitosan-Alginate NP extracted from Ferula Gummosa Gum has high potential for colon cancer treatment.

کلیدواژه ها:

Chitosan-alginate ، Ferula Gummosa Gum ، Colon cancer treatment ، Nanoparticles ، Herbal medicine