Evaluation of the Relationship between T۲*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 98
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شناسه ملی سند علمی:
JR_JKMU-31-1_008
تاریخ نمایه سازی: 27 اسفند 1402
چکیده مقاله:
Background: Cardiac iron overload causes severe cardiac complications and is a leading cause of death in beta-thalassemia major patient. T۲*CMR can detect preclinical cardiac iron overload. We evaluated the ability of ۱۲-lead electrocardiographic atrial and ventricular depolarization and repolarization parameters to predict cardiac iron loading in TM.Materials and methods: This cross-sectional study was conducted on Patients with Beta thalassemia major; all participants underwent standard ۱۲ lead electrocardiogram during a single study visit and the depolarization and repolarization parameters of ECG were measured and compared to the cardiac iron level detected by T۲*CMR, with a detectable cardiac iron cutoff of T۲*less than ۲۰ ms.Results: A total of ۲۶ patients (mean ۲۶.۱۹ years old, ۳۴.۶۲% male) were included. Mean T۲*CMR values were ۲۱.۵۳ ms (۴۶.۱۵% <۲۰ ms, ۵۳.۸۵% ≥۲۰ ms). Among ECG parameters, only Pwd, QTc and QTcd (p: ۰.۰۲۶, ۰.۰۳۰, and ۰.۰۰۶ respectively) were significantly prolonged in patients with T۲* < ۲۰ ms compared to patients with T۲*≥ ۲۰ ms. There was a statistically negative Correlation between T۲ * CMR and Pwd and QTcd (p: ۰.۰۲۸, and ۰.۰۲۱ respectively). Moreover, no correlation was found between Tp-e, Tp-e d, JTc, JTcd, Tp-e/QT, Tp-e/JT, Tp-e/JTc and T۲* values.Conclusions: PWD and QTcd can be used as an alternative to T۲*CMR to predict cardiac iron load levels in patients with beta thalassemia major.
کلیدواژه ها:
نویسندگان
yazdan ghandi
Amirkabir Hospital, School of Medicine, Department of Pediatrics, Pediatric Cardiology, Arak University of Medical Sciences, Arak, Iran
Bita Ghahremani
Student Research Committee, Arak University of Medical Sciences, Arak, Iran.
Aziz Eghbali
Pediatric Oncology, Iran University of Medical Sciences, Tehran, Iran
Parsa Yousefichaijan
Amir Kabir Hospital, Department of Pediatric Nephrology, Associate Professor of Pediatric Nephrology, Arak University of Medical Sciences, Arak, Iran.
Masoud Bahrami
Arak University of Medical Sciences