Determination of the sensitivity and secificity of hypertrophy of hyponychium as a new diagnodtic sing in down syndrome
محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 4، شماره: 1
سال انتشار: 1376
نوع سند: مقاله ژورنالی
زبان: فارسی
مشاهده: 65
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شناسه ملی سند علمی:
JR_JKMU-4-1_001
تاریخ نمایه سازی: 19 اسفند 1402
چکیده مقاله:
down syndrome is the most common known chromosomal disorder in man.this syndrome has many sings and symptoms which are variable in frequency.taking all the signs and symproms in to consideration,diagnosis of down syndrome is not a difficult task-however in the past it was difficult to diagnose this syndrome based on a single clinical sign,until hypertrophy of hyponichium was first introduced by daie(۱۹۸۸) as a new sign,that is seen in all of down syndrome patients.to determine precisely the sensitivity and specificity of this sign and its frequenxy in different fingers and toes,this research was conducted on ۶۷ infants and children with down syndrome and ۸۲ normal controls. sensitivity of hypertrophy of hyponychium in diagnose of down syndrome was found to be ۱۰۰% with the confidence interval of ۹۵%(۹۳.۲۴-۱۰۰) and the secificity of ۹۸.۷۸%(۹۲.۴۵-۹۹.۹۴) the frequency of this clinical sign was highest in the hands particularly the third and fourth fingers.thus,it is now possible to clinically ndiagnose this syndrome with high level of confidence following careful examination of fingers in newborns.
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