Synthesis of new piperazinyl quinolones and investigation of their in vitro antibacterial activities
محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 5، شماره: 3
سال انتشار: 1376
نوع سند: مقاله ژورنالی
زبان: فارسی
مشاهده: 43
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شناسه ملی سند علمی:
JR_JKMU-5-3_001
تاریخ نمایه سازی: 19 اسفند 1402
چکیده مقاله:
Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the ۷ position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro antibacterial activity. Accordingly, a series of N-L۲- oxo-۲-(۲- furyl) and N-[۲- oxyimino (۲- furyl) ethyl] piperazinyl quinolone derivatives were synthesized and evaluated for in vitro antibacterial activity. Compounds having ۲- oxo-۲-(-۲ furyl) ethyl group attached to the piperazine ring were as potent as norfloxacin and ciprofloxacin. The oximes were more active than corresponding ketones and original quinolone s against gram positive bacteria but less active against gram negative bacteria. The methyl oximes and O- benzyloximes were almost a potent as the corresponding quinolones against gram positive bacteria but less active against gram negative bacteria.
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