Survey on the Association of Seropositivity of H.pylori lgG acute myocardial infarction

Some investigatoes reported  taht there is a relationship between.H.pylori chronic infection and the prevalence of acute coronary artery disease(CAD).it is suggested that H.pylori chronic infection causes some changes in serum levels of lipids an lipoproteins and produces inflamatory proteins which could give rise to thrombogenesis.in order to comfirm any correlation between positive history of H.pylori  infection and the occurrence of acute myocardial infarction due  to CAD a study has been performed on ۱۰۴ cases of acute myocardial infarction diagnosed by history,ECG findings and elevation of the emzymes.serum levels of H.pylori  specific LgG have been measured by ELISA technique.the results have  been compared with those of ۱۰۰ healthy subjects without gaterointestinal disease.the control group comsists of ۸۰ males and ۲۰ females aged between ۴۰-۹۰ years(mean ۵۷ years for males and ۵۶ for females).the case group consisted of ۸۳ males and ۲۱ females with the age range of ۳۰-۸۵ years(mean ۵۹ years for males and ۶۴ years for females).this investigation showed that ۳۹.۴% of patients with acute myocardial infarction were positive for H.pylori  specific IgG and the remainder were negative.however only ۱۶% were positive for H.pylori specific IgG among the control group.therefore it is concluded that the seropositivity rate of any-H.pylori  IgG in the test group was greater than that of the control group and this difference was statistically significant(p=۰.۰۰۰۲).however no relationship has been found between serum level of H.pylori -specit IgG and dyspepsia.no significant relationship has been observed between H.pylori infection ad coronary artery disease risk factors(p>۰.۰۵).generally the results indicated that H.pylori infection as a risk factor may have a role in causing myocardial infarction(independent of other risk factors).

کلیدواژه ها:

Acute myocardial infarction ، Helicobacter pylori ، cardio-vascular risk factors