Plasmid-mediated Quinolone resistance genes in Pseudomonas aeruginosa isolates of burn infection
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 92
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شناسه ملی سند علمی:
JR_IJMCM-13-1_003
تاریخ نمایه سازی: 18 اسفند 1402
چکیده مقاله:
Plasmid-dependent resistance to quinolones is increasingly spreading among P. aeruginosa isolates worldwide. In this study, the evaluation of antibiotic resistance to quinolones in P. aeruginosa isolated from burn wound samples was investigated. In this descriptive study, ۷۳ burn isolates of P. aeruginosa were collected. Antibiotic susceptibility of the isolates was assessed by the disk diffusion method. Then, the frequency of the aac(۶’)-Ib, qnrS, qnrB, and qnrA genes was determined by PCR. The highest resistance was related to the antibiotics Nalidixic acid (۱۰۰%), Imipenem (۹۸.۷%), Ciprofloxacin (۹۷.۲%), Cefepime (۱۰۰%), Meropenem (۹۷.۲%), Levofloxacin (۱۰۰%), and Ofloxacin (۱۰۰%). Among ۷۳ P. aeruginosa isolates, ۴ (۵.۵%) strains containing the aac(۶')-Ib gene, ۳ (۴.۱%) strains containing the qnrA gene, ۳ (۴.۱%) strains with the qnrB gene, and ۲ (۷.۲%) strains containing the qnrS gene were detected. In total, out of ۷۳ strains of P. aeruginosa isolated from burns, ۱۲ strains (۱۶.۵%) had one or four plasmids carrying quinolone resistance genes alone or simultaneously. The expansion of quinolone-resistant plasmid genes plays an important role in the prevalence of P. aeruginosa quinolone-resistant strains in burns, and control of Pseudomonas burn wound infections with quinolones has proven difficult.
کلیدواژه ها:
نویسندگان
Malahat Alinezhad
Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
maryam Mohammadi-Sichani
Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
vajihe Karbasizade
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran