Type of Fatty Acid Intake, Serum Lipid and Lipoprotein Levels in relation to Creatinine and GFR

Correlation between fatty acids intake, serum lipid and lipoproteins with serum creatinine and kidney function in patients with renal failure has been suggested by other investigators. This relationship has not been reported for all types of fatty acids. This study was conducted to determine the association of the consumption of different type of fatty acids, serum lipids and lipoproteins with serum creatinine and glumerular filtration rate(GFR) in healthy adult subjects residing in district ۱۳ of Tehran. There were ۱۵۰۰۵ subjects participated in TLGS. ۱۴۷۰ persons were randomly selected for nutritional assessment. After excluding under- and over-reporter ۴۸۶ subjects aged over ۲۰ years remained in the study. Dietary data were collected by two ۲۴-hour dietary recalls. Serum creatinine, total cholesterol, triglyceride and HDL were measured by Selectra ۲ autoanalyzer after ۱۲ hour fasting. GFR was calculated based on serum creatinine. Mean (±SD) of serum creatinine, cholesterol, triglyceride, HDL and LDL levels and GFR were ۱.۰۴±۰.۱۶, ۲۰۱±۴۱, ۱۵۳±۱۲۵, ۴۳±۱۰, ۱۲۸±۳۷ mg/dl and ۹۹±۱۹ ml/min respectively. Subjects with saturated fatty acids intake of more than ۱۰ percent of calorie had higher levels of serum creatinine versus the others (P<۰.۰۱, ۱۰.۸±۰.۰۰۹ vs ۱.۰۳±۰.۲). People with oleic and linoleic acid intake of more than ۱۰% and ۱% of calorie ,respectively, had higher levels of serum creatinine and GFR (p<۰.۰۱). There were significant correlations between serum cholesterol, LDL, HDL, and triglyceride with serum creatinine (p<۰.۰۵, p<۰.۰۵, p<۰.۰۰۱, p<۰.۰۰۱ respectively). According to observed correlations the control of intake of desirable amount of fatty acids and serum lipid and lipoproteins level is necessary for renal health.

کلیدواژه ها:

Fatty acids intake ، Cholesterol ، Triglyceride ، LDL-C ، HDL-C ، Serum creatinine and GFR