Progressive Aspects of Colorectal Cancer: A focus on has-mir-۳۲۶

Introduction: Colorectal cancer (CRC) affects approximately ۱.۲ million individuals globally and ranks as oneof the most prevalent malignancies in the digestive tract. Due to the significant occurrence of recurrentmetastasis in CRC patients, the absence of a dependable prognostic biomarker poses challenges in predictingpatient survival post-surgery. MicroRNAs (miRNAs), small non-coding RNAs of approximately ۲۲ nucleotidesin length, transcribed from non-protein coding genes or introns, play a regulatory role in gene expression.Currently, numerous miRNAs have been implicated in carcinogenesis, tumor growth, and metastasis in CRC,suggesting their potential value as prognostic markers for the disease. Among these, miR-۳۲۶ has beenrecognized as a tumor suppressor miRNA in various human cancers. However, the lack of a comprehensiveelucidation of miR-۳۲۶ in the context of CRC led to the design of a systematic review aimed at investigating itsinvolvement in disease progression and its potential as a prognostic biomarker in CRC.Search Method: A comprehensive search of the PubMed, Scopus, and Web of Science databases employingthe keywords “hsa-mir-۳۲۶”, “miR-۳۲۶” and “colorectal cancer” from ۲۰۱۳ to ۲۰۲۳ resulted in the identificationof ۲۵ articles. After the application of predefined inclusion and exclusion criteria, a total of ۱۵ articles wereselected for thorough review.Conclusion: Our research has demonstrated the tumor-suppressive role of miR-۳۲۶ in colorectal cancer (CRC),exerting inhibitory effects on CRC cell proliferation, migration, and invasion. Furthermore, the downregulationof miR-۳۲۶ has been associated with the amplification of its target NOB۱. Notably, patients exhibiting lowerNOB۱ levels have been observed to have a more favorable prognosis compared to those with higher NOB۱expression. Collectively, these findings underscore the inhibitory role of miR-۳۲۶ in CRC progression and itspotential independent utility of miR-۳۲۶ and its target NOB۱ as prognostic biomarkers in CRC

کلیدواژه ها:

hsa-mir-۳۲۶ ، miRNA ، Colorectal Cancer ، Progression ، Prognostic Biomarker