Anticancer effect of curcumin on gastrointestinal cancers

Introduction: Malignant neoplasms originated from the gastrointestinal (GI) tract and related organs are themain indicator of cancer morbidity and mortality all over the world. Recently high polyphenol herbs with multifunctionalactions seem to be very interesting in the prevention and management of malignancies.Search Method Methods systematic electronic database search was conducted in Medline, Scopus and GoogleScholar without any language limitation, to find all published studies related to the impacts of curcumin ongastrointestinal cancers. The search key terms included ["Curcumin OR Curcuma OR Curcuminoid OR TumericOR Zedoary zedoaria OR Longa OR Curcuma longa"] AND [Cancer OR malignancy OR GastrointestinalCancer OR esophageal cancer OR gastric cancer OR pancreatic cancer OR liver cancer OR small bowel cancerOR colon cancer OR rectal cancer] in titles andabstracts. The search was conducted from inception to August۱, ۲۰۲۰. The primary database search yielded ۲۵۵ records. After careful evaluation of titles and abstracts, ۲۰articles were selected and assessed in full text. After excluding duplicate and non-original documents, ۱۱ articleswere found eligible for the final review.Conclusion: Curcumin is an important nontoxic yellow pigment of Curcuma longa, which has several antioxidantand anti-inflammatory properties. Curcumin, has been shown to be a strong antitumor agent. So far,there is lot of evidence demonstrated that curcumin has an apoptotic and anti-tumor function in cancer cells,although, it is known that it also suppresses metastatic spread and prevents cancer cell proliferation too.Curcumin exhibits its beneficial effects on inflammation and oxidative stress in various ways; it was shown tosuppress the generation of different type of cytokines, such as TNF-α and IL-۱β.curcumin has been shown to scavenge ROS through its original antioxidant function and increasing antioxidantresponse; curcumin also has been shown to modulate several transcriptional and translational factors that affectoxidative stress and oxidant defense enzymes

کلیدواژه ها:

curcumin ، gastrointestinal cancers