The Effect of Green Coffee Supplementation on MetabolicSyndrome Components: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

As there are no study reviewing the effect of green coffee supplementation on metabolic syndromefactors, this systematic review and meta-analysis were performed to summarize green coffee intervention onmetabolic syndrome components in adults.A comprehensive systematic search was conducted in online databases including Web of Science,Scopus, PubMed/MEDLINE, EMBASE, and Persian databases such as SID and Magiran up to ۲۰ March۲۰۲۳. Also, a hand search was performed by one of the researchers to reduce the missing studies. Allrandomized clinical trials comparing the effect of green coffee on metabolic syndrome components betweenintervention and control groups were included.۲۰ randomized controlled trials with a total sample size of ۸۰۴ individuals were included in thesystematic review and meta-analysis. Pooled analysis indicated that green coffee supplementationsignificantly decreased fasting blood glucose (weighted mean difference: -۲.۸۲۴ mmHg, ۹۵% CI: -۴.۴۰, -۱.۲۴, p<۰.۰۰۱), systolic blood pressure (Standardized Mean Difference: -۲.۵۳۰ mmHg, ۹۵% CI: -۴.۴۴, -۱.۲۴,p=۰.۱۰), and diastolic blood pressure (Standardized Mean Difference: -۲.۸۶۷ mmHg, ۹۵% CI: -۴.۲۶, -۱.۴۶,p<۰.۰۰۱) levels. Moreover, high-density lipoprotein concentrations increased following green coffeeintervention (weighted mean difference: ۱.۵۱۴ mg/dl, ۹۵% CI: ۰.۴۵, ۲.۵۷, p=۰.۰۰۵). However, waistcircumference and triglyceride levels did not change significantly (p > ۰.۰۵).The results of the systematic review and meta-analysis showed that green coffee supplementationsignificantly decreased fasting blood glucose, systolic blood pressure, and diastolic blood pressure butincreased high-density lipoprotein levels.

کلیدواژه ها:

Green coffee ، Chlorogenic acid ، Metabolic syndrome ، Lipid profile ، Glycemic indices