Comparison the toxicity of saffron extract(Crocus sativus L.)and tartrazine in zebrafish model

Tartrazine (TTZ) is used as colorant in food products, medicines, and cosmetics. This is also used as asubstitute for saffron (Crocus sativus L.) due to the color similar to saffron, low cost, ease of access andstability. Tartrazine is a monoazoprazolone dye, recently researches on its potential teratogenic properties inpregnant women and the possibility of passing the dye from the placenta to the fetus were often conducted onmice and confirmed the creation of teratogenic effects in mice. zebrafish is an excellent model that becomparable to the first trimester of development of human embryos and within ۷۲ hours, early developmentof zebrafish is complete and most of the internal organs, including the cardiovascular system, liver andkidney, have developed, which can be comparable to the first trimester of development of human embryos,so in this study, toxicity of tartrazine and soffron extract on zebrafish larvae has been investigated.

کلیدواژه ها:

Saffron ، Tartrazine ، Zebrafish ، Developmental toxicity ، Food colors